mTORC2 in T Lymphocyte Development and Proliferation

ALTERATION OF T-LYMPHOCYTE SUBPOPULATIONS IN SUBACUTE AND CHRONIC BRUCELLOSIS

Human brucellosis is a major health problem in developing countries. A number of patients with human brucellosis do not recover from the acute stage of the disease and pass into the chronic form. Since the pathophysiology of this change is not well understood, we studied the T-cell subsets during the acute, subacute and chronic forms of human brucellosis. In this study we found alterations...

Effect of Corynebacterium parvum on human T-lymphocyte interferon production and T-lymphocyte proliferation in vitro.

Heat-killed, preservatIve-free preparations of strain CN 6134 Cosynebacterlum parvum have been demonstrated to Induceinterferonin culturesof normaladufthuman1lymphocytes.C. parvumwas also shownto inducehuman T-lymphocytes to proliferate In vitro. The maximum inter feron and proliferative response was observed 7 days after initiationof cultureat a finalC. parvumconcentration of 140 @&g/mb. Human...

C1-esterase inhibitor blocks T lymphocyte proliferation and cytotoxic T lymphocyte generation in vitro.

We have previously shown that activated C1s complement and activated T cells cleave beta2-microglobulin (beta2m) in vitro leading to the formation of desLys58 beta2m. This process can specifically be inhibited by C1-esterase inhibitor (C1-inh). Furthermore we showed that exogenously added desLys58 beta2m in nanomolar amounts to a one-way allogenic mixed lymphocyte culture (MLC) increased the en...

Lymphocyte Development — B- and T-Cell Development

Macroautophagy in T Lymphocyte Development and Function

Macroautophagy (referred to as autophagy) is a fundamental intracellular process characterized by the sequestration of cytoplasmic compartments through double-membrane vesicles, termed autophagosomes. Recent studies have established important roles of autophagy in regulating T lymphocyte development and function. Resting T lymphocytes have basal levels of autophagy that is upregulated by T cell...